OptiVantage™ plug & play efficiency add-on


OptiBolus® allows for a uniform vascular enhancement throughout the procedure. It helps reduce the contrast load up to 40%1, maintain image quality2, all in a 1 click contrast media injection efficiency add-on.

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OptiVantage automatically & dynamically provides an optimized solution in contrast delivery

with OptiBolus® add-on, which optimizes contrast delivery in order to achieve the greatest3 contrast enhancement, with the optimum amount of contrast medium and no more.

This plug and play add-on is compatible with OptiVantage Multi-Use, OptiVantage Single-Use and OptiOne.
No need for complex settings, just let your injector automatically optimize the protocol, at the touch of a button!

Optibolus Calculator LP Banner 1

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Check your savings, up to 40%! Simulate with your own numbers and save a PDF report to share with your administration.

Optibolus 40Percent

OptiVantage offers an opportunity to balance safety with diagnostic quality2. It allows you to address concerns linked to the current global shortage of iodinated contrast media, as well as facilitate the increase in patient safety, whilst also limiting costs. All this, by focusing on the 3 following axes:

  1. Patient safety4, while saving up to 40% of contrast1
  2. Enhancement, without the need for higher concentrations 
  3. Image quality, while achieving a uniform enhancement4,5

1. Focus on patient safety4, while saving up to 40% of contrast1

Optibolus Patient Safety

Optimize the practicalities of Contrast Media: inject less iodine, meaning less radiation dose6,7, while maintaining image quality. You will be addressing the current main concerns:

  • Global iodinated contrast media shortage
  • Contrast load reduction and radiation dose reduction
  • Management of patients with renal insufficiency (potentially inject less iodine)
  • Reduce contrast waste and make savings


Given increasing reliance on CT for clinical decision making, the current global shortage of iodinated contrast media is creating manifold challenges for health systems. Health entities, such as the American College of Radiology Committee on Drugs and Contrast Media, have published statements with a variety of high-level recommendations. Therefore, imaging providers and their institutions can continue to provide high-quality patient care during times of shortage of contrast media. One of these recommendations consists in “minimizing individual doses administered, to reduce waste”.

Read the ACR statement
Optibolus Quotes (1)
" Due to the increasing speed and sensitivity of CT scanners now available, it seems relevant to look at ways to manipulate protocols and contrast delivery and therefore Iodine dose without compromising the patient diagnosis.² "

Cattini G.H and Walsh A.

Optibolus Quotes (1)
" The installation of this software will significantly alter the injection protocols and contrast delivery within CT departments allowing patients to receive the minimum iodine dose possible without compromise to their diagnosis.² "

Cattini G.H and Walsh A.

Optibolus Quotes (1)
" By using bolus-shaping software, it is possible to maintain objective image quality while reducing the contrast medium load to the patient. This has significant implications regarding clinical practice in decreasing cost and risks associated with iodinated contrast media.² "

Navin, P, Murray, A.M, Nandikamur, K, Waldron, R, Tuohy, B.

Optibolus Clinical Cases

Clinical proof

4 case studies showing contrast volume reduction, using OptiVantage with OptiBolus®

Download the case studies

2. Focus on enhancement, without the need for higher concentrations

Optibolus Focus On Enhancement
  • Achieve valuable contrast enhancement, while using lower concentrations.
  • Mimic high concentrations, while potentially reducing the occurrence of artifacts.8
  • Make savings by managing all your exams without the need for multiple product concentrations.

3. Focus on image quality, while achieving a uniform enhancement4,5

In CT applications that require long acquisition times, such as whole-body imaging & peripheral CT angiography, get a uniform contrast distribution for consistent quality of images. Prevent an overly dramatic spike of contrast at the bolus, which leads to wasted contrast.

Uniphasic injection
without add-on

OptiVantage™ injection
with add-on activated 

Normal (Uniphasic) injection technique delivers fixed flow rate from beginning to end of contrast injection. The injected contrast medium is diluted by the central blood volume before reaching and enhancing the region of interest.
A sufficient iodine mass must then be achieved to generate a diagnostically useful level of contrast enhancement.
The fixed flow rate technique yields a steadily rising vascular contrast enhancement profile, with a single peak of enhancement occurring.

Consequently, vascular enhancement is not uniform throughout the entire image acquisition, with much higher contrast on one hand, and much lower contrast on the other hand.

Guerbet solution delivers a dynamic variable flow rate along the first injection phase. Thanks to the add-on, the OptiVantage™ injector will automatically determine the best flow rate evolution, for easiest convenience and quicker workflow.
The exponential decay flow rate achieved will generate a useful contrast enhancement throughout the entire region of interest, during an extended period.

The result of which is a uniform vascular enhancement throughout the entire image acquisition.


With slower scanners, you can extend the acquisition window, potentially lowering the occurrence of missed bolus (particularly due to X-rays being launched too early or too late)

Optibolus Quotes (1)
" Achieving uniform, prolonged vascular contrast enhancement requires an injection method that is more sophisticated than the standard uniphasic or biphasic injection.⁹ "

Kyongtae T. Bae, Huy Q. Tran, Jay P. Heiken

Optibolus Quotes (1)
" Uniform prolonged vascular contrast enhancement, which is desirable for CT angiography and essential for steady-state quantification of blood volume, can be achieved by using a multiphasic exponential decay injection method.⁹ "

Kyongtae T. Bae, Huy Q. Tran, Jay P. Heiken


Download our PDF

Discover how you may reduce the contrast load up to 40%

Watch the webinars below to learn more about this technology


Reducing Contrast Media Volume in CT Imaging – From Pediatrics to Adults

Dr Charbel Saade
Clinical Applications and Education Manager, Guerbet Asia Pacific, Hong Kong SAR

Jini Park
Clinical Application Specialist, Guerbet Asia Pacific, Korea

Watch the webinar


Update on Iodinated Contrast Media Administration: The impact of New CT Technology

Dr Charbel Saade
Clinical Applications and Education Manager, Guerbet Asia Pacific, Hong Kong SAR

Pr. Dr. Davide Ippolito
Chief of Emergency Radiology, San Gerardo Hospital, Monza, Italy

Watch the webinar

Learn more about our consumables for diagnostic imaging

Visit our website to discover more about our ranges of consumables for MRI, CT and Cath Lab injection solutions



Optimal service and support designed to ensure the optimal performance of the injectors.

OptiProtect™ 3S

Diagnostic Imaging Interconnected Solutions

Driven by its commitment to advance radiology, Guerbet Diagnostic Imaging has designed a comprehensive and complete portfolio of products and solutions for diagnostic imaging.

Diagnostic Imaging Interconnected Solutions


1. Clinical Cases mentioned in the document:
1st Case: Courtesy of Chelsea Westminster Hospital NHS Foundation Trust
2nd case: Courtesy of Colin Monaghan, CT Superintendent, Liverpool Heart & Chest Hospital NHS Foundation Trust
3rd case: Courtesy of Chest & Westminster Hospital NHS Foundation Trust
4th case: Courtesy of Colin Monaghan, CT Superintendent, Liverpool Heart & Chest Hospital NHS Foundation Trust
2. Internal data: Cattini G.H and Walsh A. - A bolus shaping software used to reduce the amount of contrast given to patients during CT exams without reducing the diagnostic confidence (2010)
Navin, P, Murray, A.M, Nandikumar, K, Waldron, R, Tuohy, B., Shaped-bolus protocol reduces contrast medium volume in abdominal CT while maintaining image quality - Clinical Radiology (Oct 2016)
3. Greatest enhancement with Optibolus® versus without Optibolus®
4. Kyongtae T. Bae - Intravenous Contrast Medium Administration and Scan Timing at CT: considerations and approaches (Radiology ; July 2010 ; 256(1):32-61)
5. Markus M Schreiner et Al. - A BMI-adjusted ultra-low-dose CT angiography protocol for the peripheral arteries-Image quality, diagnostic accuracy and radiation exposure (Eur J Radiol ; August 2017 ; 93:149-156)
6. Radiology Department, Ulster Hospital - Belfast/UK - Contrast Reduction in pre-TAVI assessment - POSTER C-1206 ECR 2014 - "The overall volume of iodine administered to the patient can be reduced by approximately 35% (from 37.5g to 24.5g) without sacrificing image quality"
7. Thomsen H. S., Morcos S. K., Barrett B. J. - Contrast-induced nephropathy, the wheel has turned 360 degrees - Acta Radiologica (July 2008; 49.646-657)
8. Kerl JM; Ravenel JG; Nguyen SA; Suranyi P; Thilo C; Costello P; Bautz W; Schoepf UJ - Split-Bolus Injection of Diluted Contrast Medium for Visualization at Coronary CT Angiography - Radiology. 2008 May;247(2):356-64
8b. Utsunomiya D. & Al. - Cardiac 16-MDCT for Anatomic and Functional Analysis: Assessment of a Biphasic Contrast Injection Protocol - AJR:187, September 2006
9. Kyongtae T. Bae, Huy Q. Tran, Jay P.Heiken - Multiphasic Injection Method for Uniform Prolonged Vascular Enhancement at CT Angiography: Pharmacokinetic Analysis and Experimental Porcine Model - Radiology (Sept. 2000; 216:872-880)


OptiBolus® may be subject to an additional fee; Can differ from country to country; For more information, please contact your local Guerbet representative.

OptiVantage DH Contrast Media Injector is a medical device intended for use by qualified healthcare professionals, it is a contrast delivery system and is designed to inject radiopaque contrast media into a patient’s vascular system to obtain diagnostic images when used with computed tomography (i.e. «CT») equipment.
Ensure that injection from multi-dose containers and to more than one patient respects the valid rules of good practice and the marketing authorization (MA) of the contrast agent and local regulatory requirements.

Class IIb/CE TÜV SÜD 0123 Manufacturer: Liebel-Flarsheim Company LLC EC Rep: Guerbet
For use only in countries with applicable health authority registrations.
For complete information about precautions and optimal usage conditions, we recommend consulting the instruction for use supplied with these devices or by your local Guerbet representative(s).

OptiVantage, OptiBolus® are trademarks of Guerbet

© Guerbet Group 2022. P23002374 – October 2023