These medical devices are intended for use by medical imaging and diagnostic healthcare professionals. For complete information about precautions and optimal usage conditions for these medical devices, we recommend consulting the instructions notices/user’s manuals.
Ensure that injection from multi‐dose containers and to more than one patient respects the valid rules of good practice and the marketing authorization (MA) of the contrast agent and local regulatory requirements. The multiple use of manyfill^™ disposables is intended for multi‐patient markets. Use a new secufill^™ patient line for each patient.

OptiVantage^™ injector is a medical device (Class: II b, CE0123) intended for use by medical imaging and diagnostic health professionals, for injecting radiopaque contrast media and saline into a patient’s vascular system during CT examinations.
OptiBolus^® is a bolus shaping software that provides uniform contrast enhancement and extends image acquisition window for dynamic scanning procedures.
OptiVantage^™ disposables are medical devices (Class: II a, CE0123). Notified Body: TUV SUD Product Service GmbH. Manufacturer: Liebel-Flarsheim Company LLC, 2111 East Galbraith Road, Cincinnati, OH 45237, USA
Secufill^™: single use patient line with double valve for CT & MRI (Class II a medical devices, CE0459).
Manyfill^™: multi-use filling/injection set for CT (Class II a medical devices, CE0459).
Contrast&Care^®: medical device (Class I, CE).
Notified Body: LNE G-Med. Manufacturer: Medex, 240 Allée Jacques Monod, 69800 Saint-Priest, France
OptiVantage^™, OptiBolus^®, Patency Check^®, Timing Bolus^®, OptiProtect™, LF™, Contrast&Care^®, secufill^™, manyfill^™ are trademarks of Guerbet. Patents pending and issued patents. ^© Copyright 2018 Guerbet – All rights reserved.

P23002082 - May 2023

*HIS: Hospital Information System including PACS (Picture Archiving communication System), RIS (Radiology Information System) and EMR (Electronic Medical Record)

1.    Refer to the Manyfill Instructions For Use. Internal data Technical File Ref. M0008-000024 and D6648
2.    Vermeulen C, Noury B, Dolle F, et al. Microbial Safety Assessment of a Double Check-Valve Patient Line in a Multiuse Contrast Delivery System. Radiol Technol. 2015;87(2):139-49.
3.    May be subject to an additional fee. Can differ from country to country. For more information please contact your local Guerbet representative. Navin P, Murray AM, Nandikumar K, et al. Shaped-bolus protocol reduces contrast medium volume in abdominal CT while maintaining image quality. Clinical Radiology 2017;72(3):265.e1-5.
4.    Refer to the Contrast&Care^® Instructions for Use.
5. May be subject to an additional fee. Can differ from country to country. For more information please contact your local Guerbet representative.
6. Time saved in bi-liquid multi-use versus in bi-liquid single-use
7. Certified by Guerbet as compatible on Guerbet injectors - data on file                                                                      8. Clinical Cases mentioned in the following document: https://www.guerbet.com/media/a0fnjjmm/optibolus-case-studies.pdf
1st Case: Courtesy of Chelsea Westminster Hospital NHS Foundation Trust
2nd case: Courtesy of Colin Monaghan, CT Superintendent, Liverpool Heart & Chest Hospital NHS Foundation Trust
3rd case: Courtesy of Chest & Westminster Hospital NHS Foundation Trust
4th case: Courtesy of Colin Monaghan, CT Superintendent, Liverpool Heart & Chest Hospital NHS Foundation Trust
9. Internal data: Cattini G.H and Walsh A. - A bolus shaping software used to reduce the amount of contrast given to patients during CT exams without reducing the diagnostic confidence (2010)
Navin, P, Murray, A.M, Nandikumar, K, Waldron, R, Tuohy, B., Shaped-bolus protocol reduces contrast medium volume in abdominal CT while maintaining image quality - Clinical Radiology (Oct 2016)                                          10. Data on file